Fever and leukemoid reaction: a rare paraneoplastic manifestation of bladder carcinoma.

Sir, Paraneoplastic syndromes are defined as nonmetastatic systemic effects that accompany malignant disease. These syndromes may occur in up to 10-15% of malignancies. A few paraneoplastic syndromes have been reported in metastatic transitional cell carcinoma including hypercalcemia, thrombocytosis, eosinophilia, nephrotic syndrome, acanthosis nigricans, dermatomyositis, polymyositis, and leukemoid reaction.[1] Leukemoid reaction has rarely been reported in patients with primary bladder carcinomas. We report a rare case of leukemoid reaction and fever associated with transitional cell carcinoma of the urinary bladder.